The Stroke Research and Therapeutics Laboratory (SRTL) is involved to dissect the pathophysiology of ischemic and hemorrhagic stroke as the basis for the development of novel therapeutic options for stroke patients. SRTL is an integral part of NIPER-A’s translational research strategy. The main expertise of the laboratory includes experimental stroke models (transient & permanent focal cerebral ischemia, global ischemia, cardiac arrest model of ischemia and subarachnoid haemorrhage) and methodologies for the investigation of alterations in cerebral microcirculation.
The thematic focus of Pallab’s team is identifying the molecular mechanisms of intra-arterial stem cell mediated neuroprotection after ischemic stroke. The laboratory also works on the pathophysiology of microcirculatory dysfunction (including the blood-brain barrier) and small vessel disease (SVD). The lab is interested in studying neuroendocrine regulation in ischemic stroke, stroke induced optic neuropathy, strategies of mitochondrial and endoplasmic reticulum protection by stem cell therapy and regulatory RNA mediated stem cell engineering.
In the future, the laboratory also aims to study the molecular cross talk of Parkinson’s disease following stroke.
Primary techniques: in vitro hypoxia model, in vivo models of ischemic and hemorrhagic stroke, in vivo small animal imaging, intra–arterial stem cell therapy, histology/immunohistochemistry, microdissection microscopy, fluroscence imaging, behavioural analysis, mitochondria study, biochemical and molecular biology study.
Models: Cell culture, Rat, Mouse.